A payment rule can be specified to be attached to the pending payment, the payment rule can further manage the conditions to collect the payment, for example it could specify to use virtual cards only and not a guest card.
You can only select a "payment rule" in Hotelbeds.com after you have created one.
Settings > Payments > Payment Rules and set Payment Source = Virtual card only > then select the payment rule in the channel manager setup for Hotelbeds.com
If you manually charge virtual credit cards please note that they can only be charged after the card activation date.